Fig. 2

Quantification of MMP9-stained vessels in CAA-NH and CAA-ICH cases, classified according to staining grade. The percentage of leptomeningeal vessels with full (a), but not partial (b) MMP9 staining was higher in CAA-ICH cases compared to CAA-NH cases. Serial sections of a representative CAA-NH (c, d) and a representative CAA-ICH (e, f) case stained for Aβ (c, e) and MMP9 (d, f). Scale bar = 200 μm. Compared to CAA-NH cases, CAA-ICH cases had more fully Aβ-stained leptomeningeal vessels that were also fully stained for MMP9 (g), but fewer Aβ-stained vessels that had partial MMP9 staining (h). Plots indicate median values with interquartile range. CAA-NH = CAA-non haemorrhagic, CAA-ICH = CAA-related ICH. *p ≤ 0.05; **p ≤ 0.01