Fig. 2

Semi-quantitative analysis of hp-tau and p-αSyn accumulation in 10 regions: the hippocampal CA1 and CA3 areas, dentate gyrus (DG), motor area (MO), somatosensory area (SO), entorhinal cortex (ENT), piriform cortex (PIR), amygdala (AMY), striatum (STR), and substantia nigra (SN), in rTg4510 mice fed the standard (n = 11) or doxycycline (dox) diet (n = 10). The accumulation of hp-tau was decreased in all regions studied in rTg4510 mice fed the dox diet (*p < 0.01, a The accumulation of hp-tau was decreased in CA1, CA3, MO, SO, ENT, PIR, AMY, and STR in rTg4510 mice fed the dox diet (*p < 0.01, b). Positive correlations were observed between the average accumulation of hp-tau and p-αSyn in each region (r = 0.85, p < 0.01, c), and between hp-tau and p-αSyn accumulation in CA1 (r = 0.80, p < 0.01, d), CA3(r = 0.94, p < 0.01, e), MO (r = 0.74, p < 0.01, f), ENT (r = 0.77, p < 0.01, g), PIR (r = 0.88, p < 0.01, h), and AMY (r = 0.86, p < 0.01, i) in rTg4510 mice. Colors: red, CA1; purple, CA3; deep red, DG; pink, MO; gray; SO; black, ENT; green; PIR; blue, AMY; light blue, STR; orange, SN. Diagrams: circular dot, rTg4510 mice fed the control diet; circle, rTg4510 mice fed the dox diet