Fig. 8

Triple phosphorylation of Ser202, Thr205, and Ser208 promotes tau mislocalization and aggregation, leading to the formation of NFT. 1) Physiologically, most tau protein is found in neuronal axons. 2) Tau phosphorylation at Ser202 and Thr205 leads to tau mislocalization to the soma and dendrites. 3) Combined phosphorylation of tau at Ser202, Thr205, and Ser208 enhances formation of tau filaments that lead to neurofibrillary tangles. Figure was created with Biorender