Table 2 Summary statistics from tissue immunohistochemistry image analysis. The table shows the number of individuals and cells counted for each tissue region and subject group. The number of neurons or glial cells and RBM45 nuclear and cytoplasmic inclusions were counted as described in the Methods section. For each subject, a total of 8 fields per region (hippocampal dentate gyrus or lumbar spinal cord) were evaluated. FTLD-TDP = frontotemporal lobar degeneration with TDP-43 proteinopathy
Group | N | Total Cells | Mean Cells/ Field | SEM Cells/ Field | Mean Nuclear RBM45 Inclusions/Cell | SEM Nuclear RBM45 Inclusions/Cell | Mean Cytoplasmic RBM45 Inclusions/Cell | SEM Cytoplasmic RBM45 Inclusions/Cell |
|---|---|---|---|---|---|---|---|---|
Dentate Gyrus Granule Cells | ||||||||
 Control | 10 | 4145 | 51.81 | 4.92 | 0.44 | 0.09 | 0 | 0 |
 AD | 5 | 1590 | 39.75 | 8.32 | 0.98 | 0.34 | 0.044 | 0.051 |
 ALS | 8 | 2943 | 45.98 | 5.98 | 1.49 | 0.27 | 0.048 | 0.055 |
 FTLD-TDP | 6 | 1962 | 40.92 | 5.81 | 2.38 | 0.23 | 0.109 | 0.072 |
Spinal Cord Glial Cells | ||||||||
 Control | 9 | 693 | 9.62 | 1.18 | 0.23 | 0.06 | 0 | 0 |
 ALS | 15 | 2689 | 22.35 | 1.74 | 1.04 | 0.18 | 0.11 | 0.47 |
Spinal Cord Motor Neurons | ||||||||
 Control | 9 | 308 | 4.29 | 0.53 | 0 | 0 | 0 | 0 |
 ALS | 15 | 351 | 2.91 | 0.42 | 0 | 0 | 0.15 | 0.14 |