Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes

Table 2 Transmission of sCJD and iCJD with variable PrP^Sc allotypes into tg66 and tgRM mice overexpressing human PrP^C-M129

^aNeuropathological subtype of cases originally described in [28]. All cases are sCJD except where noted as iCJD. CB cerebellar cortex, CC cerebral cortex
^bCases originally described in [28]. MV2K = CJD subtype MV2 with kuru (K) plaques; 2C = Type 2 PrP^Sc in the cortex
^cPercentage of PrP^Sc in the inoculum which is PrP^Sc-M129 shown as mean + standard deviation. Data adapted from [28]. **** p = 0.0001 versus case 4 by unpaired student’s t-test; ***p = 0.02 versus case 10, 0.007 versus case 20, 0.009 versus case 7, and 0.003 versus case 18 using Tukey’s multiple comparisons test; ** p = 0.01 versus case 9 (CbC) and 12 using Tukey’s multiple comparisons test
^dDPI = mean days post-infection + standard deviation
^eNumber of mice with clinical disease over total number of mice inoculated. Intercurrent deaths are not included

ISSN: 2051-5960