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Table 2 Transmission of sCJD and iCJD with variable PrPSc allotypes into tg66 and tgRM mice overexpressing human PrPC-M129

From: Transmission characteristics of heterozygous cases of Creutzfeldt-Jakob disease with variable abnormal prion protein allotypes

 tg66tgRM
Case #aSubtypebPrPSc-M129cDPIdClin/totaleDPIdClin/totale
ControlMM1100187 ± 139/9211 ± 118/8
3MV1 + 2C100 ± 0****196 ± 198/8218 ± 137/8
4MV1 + 2C34 ± 5>  6110/7>  6510/6
9 (CC)MV2K + 2C82 ± 8**>  5020/5>  6620/7
9 (CbC)MV2K + 2C33 ± 8488 ± 175/5519 ± 262/4
12MV2K + 2C29 ± 20497 ± 1322/54711/7
19 (iCJD)MV2K66 ± 4***184 ± 23/3214 ± 97/7
10MV2K43 ± 2407 ± 367/7503 ± 545/6
20 (iCJD)MV2K39 ± 6482 ± 342/73731/5
7MV2K38 ± 18398 ± 136/6448 ± 184/5
18 (iCJD)MV2K36 ± 5238 ± 175/8296 ± 464/7
11MV2C85 ± 1401 ± 212/8>  7900/8
  1. aNeuropathological subtype of cases originally described in [28]. All cases are sCJD except where noted as iCJD. CB cerebellar cortex, CC cerebral cortex
  2. bCases originally described in [28]. MV2K = CJD subtype MV2 with kuru (K) plaques; 2C = Type 2 PrPSc in the cortex
  3. cPercentage of PrPSc in the inoculum which is PrPSc-M129 shown as mean + standard deviation. Data adapted from [28]. **** p = 0.0001 versus case 4 by unpaired student’s t-test; ***p = 0.02 versus case 10, 0.007 versus case 20, 0.009 versus case 7, and 0.003 versus case 18 using Tukey’s multiple comparisons test; ** p = 0.01 versus case 9 (CbC) and 12 using Tukey’s multiple comparisons test
  4. dDPI = mean days post-infection + standard deviation
  5. eNumber of mice with clinical disease over total number of mice inoculated. Intercurrent deaths are not included
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