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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

Fig. 6

Heatmap of the 44 genes related to endocytosis that were differentially expressed genes between DS and euploid fibroblasts. Each column represents a cell line, each row a specific probe. Red indicates relative gene upregulation, and blue indicates relative gene downregulation. Hierarchical clustering classified DS subjects together and separated from euploid (2 N), showing a differential expression pattern between the groups. APP and SYNJ1 genes are highlighted in red bold, while differentially expressed genes related to cargo sorting from early endosomes to multivesicular bodies (MVB) toward the degradation pathway are highlight in black bold

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