Fig. 3
From: Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome
Electron microscopy after high-pressure freezing in fibroblasts from individuals with DS. a Electron micrograph of a euploid fibroblast (2N_2) and a fibroblast from an individual with DS (DS_1). Squared zones are enlarged in top left corners (scale bar = 500 nm); b Quantification of early endosomal area shows no significant difference between euploid and DS fibroblasts (mixed effects ANOVA, genotype p-value = 0.49); c Quantification of early endosome numerical density reveals that early endosomes are significantly more dense in fibroblasts from individuals with DS (mixed effects ANOVA, genotype *p-value = 0.031)