Table 2 Overview of the detected metabolites in cerebrospinal fluid
From: Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients
Parent Drug | Metabolite | Structure | Active / Inactive |
|---|---|---|---|
imatinib | demethylated imatinib = CGP74588 | known | active |
imatinib | hydroxylated imatinib = AFN911 | known | unknown |
imatinib | N-glucuronidated imatinib | unknown | unknown |
imatinib | O-glucuronidated imatinib | known | unknown |
ribociclib | demethylated ribociclib = LEQ803 | known | active |
ribociclib | hydroxylated LEQ803 | unknown | unknown |
vorinostat | succinanilic acid | known | inactive |
vorinostat | glucuronidated vorinostat | known | inactive |