Skip to main content

Table 2 Overview of the detected metabolites in cerebrospinal fluid

From: Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients

Parent DrugMetaboliteStructureActive / Inactive
imatinibdemethylated imatinib = CGP74588knownactive
imatinibhydroxylated imatinib = AFN911knownunknown
imatinibN-glucuronidated imatinibunknownunknown
imatinibO-glucuronidated imatinibknownunknown
ribociclibdemethylated ribociclib = LEQ803knownactive
ribociclibhydroxylated LEQ803unknownunknown
vorinostatsuccinanilic acidknowninactive
vorinostatglucuronidated vorinostatknowninactive