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Table 1 Sample characteristics of the different cohorts analyzed. Differences in age and PMI between cases and controls were assessed using t-test or Wilcoxon test, according to the data distribution. Sex distribution was assessed using the Fisher’s Exact test

From: Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

A (Cohort 1) MSA (n = 19)HC (n = 19)p
Age70.2 ± 7.469.6 ± 6.5t = − 0.311; p = 0.757
PMI10.6 ± 10.112.0 ± 10.8W = 175, p = 0.884
Males1010p = 1.000
Females99
 MSA-P (n = 5)HC (n = 19)p
Age66.8 ± 5.869.6 ± 6.5t = − 1.168; p = 0.255
PMI15.2 ± 5.912.0 ± 10.8W = 60.5; p = 0.374
Males3 (60.0)10 (52.6)p = 1.000
Females2 (40.0)9 (47.4)
 MSA-C (n = 5)HC (n = 19)p
Age72.2 ± 6.669.6 ± 6.5t = 0.366; p = 0.718
PMI19.4 ± 13.212.0 ± 10.8W = 66.5; p = 0.188
Males4 (80.0)10 (52.6)p = 0.356
Females1 (20.0)9 (47.4)
B (Cohort 2)a MSA (n = 48)HC (n = 47)p
Age64.5 ± 8.084.2 ± 9.1W = 159.5; p = 5.6E-13
PMI61.7 ± 24.059.9 ± 28.2W = 1172; p = 0.746
Males (%)21 (43.8)16 (34.0)p = 0.402
Females (%)27 (56.3)31 (66.0)
 MSA_P (n = 37)HC (n = 47)p
Age64.8 ± 8.584.2 ± 9.1W = 129.5; p = 2.6E-11
PMI63.2 ± 24.659.9 ± 28.2W = 930; p = 0.589
Males (%)14 (37.8)16 (34.0)p = 0.820
Females (%)23 (62.1)31 (66.0)
 MSA_C (n = 11)HC (n = 47)p
Age63.5 ± 6.484.2 ± 9.1W = 30; p = 6.0E-06
PMI56.9 ± 22.259.9 ± 28.2W = 242; p = 0.751
Males (%)7 (63.6)16 (34.0)p = 0.093
Females (%)4 (36.4)31 (66.0)
C (Cohort 1 - LCM)b MSA (n = 6)HC (n = 6)p
Age70.0 ± 7.772.0 ± 7.0t = −0.469; p = 0.650
PMI16.3 ± 14.49.4 ± 11.0W = 26.5; p = 0.199
Males4 (66.7)2 (33.3)p = 0.547
Females2 (33.3)4 (66.7)
  1. aOne MSA-P sample was removed after the PCA analysis (Final sample size: MSA = 47; MSA- P = 36; MSA-C = 11; HC = 47)
  2. bTwo MSA and one HC samples were removed after PCA analysis (Final sample size: MSA = 4; HC = 5)
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