Fig. 1
From: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Alterations in microglial and macrophage phenotype in HDLS. Microscopic comparison of 4 macrophage markers in a representative HDLS case (case #7) and a representative normal control (case #8). IBA-1 expression (a & b) is decreased in the white matter of HDLS. Similarly, P2RY12 expression (c & d) is decreased in white matter of HDLS. Many amoeboid CD68 (e & f) macrophages are observed in HDLS lesional white matter. Presence of parenchymal CD163 (g & h) positive cells are confined to the lesional white matter of HDLS, with almost no cells detected seen in normal parenchyma. GM = gray matter, WM = white matter. Dotted line separates gray and white matter. Scale bar = 100 μm