Table 2 PCR array data showing the differential expression of cell death pathway genes in IFA aloned and MOG + IFA immunised animals injected with cytokine viral vectors compared to GFP vector injected control animals at 28 days post injection. Genes highlighted in bold and italics showed a greater than 2-fold significant increase

Aifm1

(1.28, 2.28)

(1.45, 3.10)

Ar

(1.47, 5.18)

(2.09, 5.85)

Atp6v1g2

(1.19, 3.45)

(1.92, 3.71)

Bax

(0.95, 1.96)

(1.02, 2.04)

Bid

(0.94, 2.95)

(1.53, 2.33)

Birc3

(2.12, 6.54)

(3.48, 6.23)3.48, 6.23)(1.47, 2.62)

Bmf

(0.87, 3.59)

(1.47, 2.62)

Capn2

(1.31, 2.69)

(1.52, 3.05)

Capn3

(1.53, 4.06)

(1.42, 2.98)

Capn5

(1.66, 2.29)

(1.53, 2.41)

Capn7

(1.04, 2.55)

(1.57, 2.57)

Capns1

(1.44, 3.63)

(1.69, 3.92)

Cd40

(2.30, 7.25)

(2.59, 5.23)

Cetn1

(1.14, 3.59)

(1.04, 3.14)

Cyba

(2.06, 8.79)

(3.39, 4.71)

Cybb

(3.33, 30.73)

(5.71, 16.64)

Cyld

(2.06, 3.93)

(1.06, 3.39)

Defb1

(3.01, 8.73)

(0.27, 5.97)

Dpys14

(1.32, 2.26)

(1.37, 2.79)

Fadd

(1.06, 2.35)

(1.19, 3.09)

Fas

(1.45, 5.54)

(1.77, 2.71)

Faslg

(0.88, 2.34)

(1.38, 2.81)

Foxi1

(0.00001, 65.05)

(0.00001, 72.42)

Glud1

(1.35, 2.78)

(1.36, 2.93)

Glul

(1.39, 3.18)

(0.95, 4.06)

Grb2

(1.95, 3.34)

(1.83, 3.55)

Hspbap1

(1.62, 2.55)

(1.45, 2.98)

Kcnip1

(1.03, 2.51)

(1.43, 3.36)

Madd

(1.03, 2.22)

(1.45, 3.10)

Myd88

(1.56, 4.27)

(1.99, 3.04)

Nfkb1

(1.69, 3.00)

(1.53, 2.95)

Ngf

(1.36, 2.27)

(1.39, 3.35)

Ngfr

(1.68, 4.96)

(1.28, 3.90)

Nox1

(1.77, 5.11)

(2.53, 5.94)

Parp1

(1.06, 2.64)

(1.48, 2.48)

Parp2

(0.90, 1.60)

(1.15, 1.57)

Ppid

(1.38, 2.80)

(1.59, 2.87)

Pygl

(1.84, 6.28)

(1.83, 4.79)

Rab25

(1.27, 3.83)

(1.45, 3.38)

Dennd4a

(1.25, 2.67)

(1.57, 2.70)

Ripk1

(1.29, 2.31)

(1.26, 2.62)

Ripk2

(1.17, 2.10)

(1.43, 2.34)

Ripk3

(1.83, 6.48)

(2.00, 3.42)

Sp1

(1.31, 2.53)

(1.46, 2.61)

Spata2

(1.89, 2.82)

(1.44, 3.88)

Tmem123

(1.60, 4.11)

(1.98, 2.75)

Tmem57

(1.12, 4.14)

(1.11, 2.97)

Tnf

(1.92, 7.71)

(1.69, 5.06)

Tnfrsf10b

(1.09, 3.29)

(1.32, 3.14)

Tnfrsf14

(0.00001, 120.6)

(0.00001, 79.86)

Tnfrsf17

(1.74, 2.47)

(1.58, 2.73)

Tnfrsf1a

(1.80, 3.44)

(1.55, 2.86)

Tnfrsf1b

(3.58, 8.46)

(3.36, 4.89)

Tnfrsf25

(1.01, 2.80)

(0.78, 3.74)

Tnfrsf8

(2.84, 5.63)

(3.14, 5.15)

Tnfrsf10

(1.57, 3.70)

(1.82, 3.37)

Tradd

(1.71, 2.52)

(1.46, 2.74)

Traf2

(1.60, 2.99)

(1.64, 3.11)

Txnl4b

(1.49, 4.32)

(1.62, 2.84)