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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 7

Unilateral intranigral administration of BSSG induces bilateral degeneration of the SNpc neurons. a Representative merged micrographs of slices stained with F-J C (green) and TH immunofluorescence (red) at the time displayed at the left margin in every row. The scale bar = 50 μm is common to all micrographs. b Graphs showing IFAD of F-J C and TH in the conditions of the panel a. The bars stand for the mean ± S.E.M. calculated from the measurements in three anatomical levels. n = 3 independent rats per time point in the BSSG group; n = 6 for Mock and UT groups. *, BSSG group compared with the control groups. When compared with the BSSG effect over time, & vs. 60 and Ω vs. 120 days after the lesion. Two-way ANOVA, Bonferroni post-test. p < 0.05. Analysis of confocal micrographs taken c at days 30 and d 120 after the BSSG administration. The top left and bottom right panels correspond to the orthogonal projections from 1 μm z-confocal optical sections. The right top panels are the integrated images, and the bottom left panels are a horizontal optical Z-sections

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