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Fig. 11 | Acta Neuropathologica Communications

Fig. 11

From: Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Fig. 11

Unilateral intranigral administration of BSSG causes progressive motor and non-motor impairments. a Contralateral and b ipsilateral response to the vibrissae stimulation. c Asymmetry in the number of contacts of the forelimb paws on a transparent cylinder wall. d Time traveled and e claudications during displacement on a narrow beam. f Locomotor activity during the exploration of a new environment. g Asymmetry in discrimination of olfactory stimuli regularly distributed on each side of a corridor floor. h Depressive-like behavior evaluated by the immobility time in a swim tank. i Working and j episodic memory alteration evaluated by the exploration of the novel object in the open-field arena. *, BSSG group compared with the control groups. When compared with the BSSG effect over time, # vs. 30, & vs. 60 and Ω vs. 120 days after the injury. Each bar represents the mean ± S.E.M. from n = 8 rats per experimental group and time. Two-way ANOVA, Bonferroni post-test. p < 0.05

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