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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism

Fig. 5

Intraneuronal N-tr-Aβ detected with the mAb 4G8, in subpopulations of GABAergic neurons expressing parvalbumin (PVA) and somatostatin (SST) shown in triple immunostainings in a 10-year-old dup-15/autism individual. GABAergic neurons (arrows) and synapses were stained blue for GAD67 and GAD65, respectively. All the cells expressing parvalbumin were GAD65/67 positive and appeared to be cells with a high load of N-tr-Aβ, while the SST-expressing neurons had low levels of N-tr-Aβ deposits. The scale bars show 20 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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