Table 5 Sequence homology between different mimotopes and bacterial/fungal/parasitic proteins. All proteins are located intracellularly, but might be released as a consequence of immune-mediated damage
From: Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes
Mimotope | # Mimotope sequence # Quality of matcha # Organismal protein sequence # | Protein name Protein sequence ID[Organism] | Possible disease association of bacteria/fungi/parasites or presence in human microbiome |
|---|---|---|---|
III-01 | 5 HHHPIMPR 12 HH + PIMPR 183 HHQPIMPR 190 | DUF3306 domain-containing protein WP_083797754.1 [Vibrio Metschnikovii]. | |
|  | 5 HHHPIMPR 12 HHHPI + PR 160 HHHPILPR 167 | N-succinylarginine dihydrolase WP_058459851.1 [Fluoribacter bozemanae = Legionella bozemanae] Same alignment seen for Legionella anisa and Legionella longbeachae | |
I-04 | 3 YHVHPTPF 10 Y + VHPTPF 519 YQVHPTPF 526 | Hypothetical protein CORT_0F01650 XP_003870521.1 [Candida orthopsilosis Co 90–125] | Rare infections [47] |
| Â | 3 YHVHPTP 9 YHVHPTP 560 YHVHPTP 566 6 HPTPFK 11 +PTPFK 57 QPTPFK 62 | Vacuolar sorting-associated protein EGC49414.1 [Histoplasma capsulatum H88];Same alignment seen forvacuolar protein sorting-associated protein 27 EER41546.1 [Histoplasma capsulatum H143] Hypothetical protein WP_080024432.1 [Helicobacter pylori] | Histoplasmosis [48] Gastritis, peptid ulcers [49] |
I-13 | 2 PFHFLHH 8 PFHFLHH 3450 PFHFLHH 3456 7 HHHWSQ 12 HHHWS+ 245 HHHWSH 250 | RAVE 1 carboxy-terminal protein RQX74768.1 [Toxoplasma gondii] Chain A, Enoyl-CoA hydratase/isomerase family protein 4HC8_A [Mycobacterium tuberculosis] | Toxoplasmosis [50] Tuberculosis [51] |
IV-04 | 1 WPWHAH-GNTRGI 12 WPWHAH GN R I 119 WPWHAHLGN-RVI 130 1 WPWHAHGN 8 W WHAHGN 393 WAWHAHGN 400 1 WPWHAHGNTR 10 W WHAHGN R 243 W-WHAHGNSR 251 4 HAHGNTRGI 12 HA GNTRG+ 252 HARGNTRGV 260 5 AHGNTRGI 12 A + GNTRG+ 253 AQGNTRGV 260 1 WPWHAHGN 8 W WHAHGN 123 WRWHAHGN 130 | Glycosyltransferase family 2 protein WP_040707114.1 [Nocardia takedensis]; Same alignment seen in [Nocardia pneumoniae] Gentisate 1,2-dioxygenase VFT64169.1 [Pseudomonas aeruginosa] MFS transporter WP_115184045.1 [Serratia multispecies, among them S. plymuthica, S. quinivorans, S. proteamaculans, S. liquefaciens, S. grimesii] Hop family adhesin BabA CEI71366.1 [Helicobacter pylori] Hop family adhesin BabA WP_000716277.1 [Helicobacter pylori] cupin domain-containing protein, partial WP-129361314.1 [Enterobacter cloacae complex sp. 2DZ2F16B1] | Nocardiosis [52] Different types of infections [53] Different types of infections [54] Gastritis, peptid ulcers [49] Gastritis, peptid ulcers [49] Complex includes common nosocomial pathogens capable of producing a wide variety of infections [55] |