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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Fig. 3

Mitochondrial respiratory chain deficiency in sCJD hippocampus (CA4). a Representative photographs of mitochondrial respiratory chain complex stainings (complex I: NDUFB8, complex II: SDHA, complex III: UQCRC2, complex IV: MTCO1, complex V: ATP5A) and VDAC1 in the CA4 region of controls (top row), sCJD molecular subtypes VV2 (middle row) and MM1 (lower row). Mitochondrial respiratory chain deficient neurons are visible in both MM1 and VV2 (+: positive neurons, #: deficient neurons). Decreased staining is observed both in neurons and in surrounding neuropil. Scale bar: 100 μm. b Scatter plots showing the fraction of deficient neurons in the CA4 region of the hippocampus. Each dot represents the mean percentage of deficient neurons for each respiratory complex per individual with sCJD (VV2 or MM1) or control. Bars show mean and 95%- confidence intervals]

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