Fig. 2

Donors with a clinical diagnosis of PD showed a wide variety of neuropathological hallmarks in nigrostriatal regions. a. 85% of clinical PD donors showed nigral degeneration combined with α-synuclein positive Lewy bodies (arrows) and Lewy neurites in the substantia nigra. b-c. Α-synuclein positive glial cytoplasmic inclusions (GCIs) in the substantia nigra (b) and striatum (c), fitting a neuropathological diagnosis of MSA. d. Α-synuclein positive GCIs combined with Lewy bodies (arrows) in the substantia nigra. e-f. HPF-tau positive globose tangles and neurites in the substantia nigra (e) and a globose tangle and coiled body (asterisk) in the striatum (f) of a donor with a neuropathological diagnosis of PSP. g-h. In the striatum of a donor with combined PSP tau pathology and Lewy pathology, HPF-tau positive coiled bodies (asterisks) and thorny astrocytes (g) were present as well as α-synuclein positive Lewy bodies (arrows in h). i. One donor with early onset PD showed nigral degeneration and gliosis combined with HPF-tau positive pathology in the basal ganglia, thalamus and subthalamic nucleus. Image I shows neuritic threads and neuronal cytoplasmic inclusions in the nucleus basalis of Meynert. j-k. Vascular lesions were found in the nigrostriatal regions of several donors, including a donor with a microvascular lesion in the putamen (j) and a donor with wide perivascular spaces and a lacunar state of the striatum (k). l. In one donor with familial tremor-predominant parkinsonism, no protein aggregates or vascular lesions were present. The substantia nigra did not show neuronal loss, but mild spongiform changes were present. The scale bar in a applies to images a-i