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Table 3 Comparison of the characteristics and prognoses of histological grade II–IV spinal cord glioma patients with or without the H3 K27M mutation

From: The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation

 Histological Grade IIHistological Grade IIIHistological Grade IV
H3 wildtypeH3 K27M-mutantP-valueH3 wildtypeH3 K27M-mutantP-valueH3 wildtypeH3 K27M-mutantP-value
Number3714 614 57 
Age (year)2936n.s3035n.s51200.0101
 (6–54)(10–51) (13–63)(9–52) (30–63)(13–36) 
Gender  n.s  n.s  n.s
male25(68%)7(50%) 4(67%)9(64%) 2(40%)2(29%) 
female12(32%)7(50%) 2(33%)5(36%) 3(60%)5(71%) 
Location  n.s  n.s  n.s
C16(43%)5(36%) 1(17%)3(21%) 2(40%)2(29%) 
C-T5(14%)1(7%) 0(0%)3(21%) 1(20%)3(43%) 
T13(35%)7(50%) 4(67%)6(43%) 2(40%)2(29%) 
T-L3(8%)1(7%) 1(17%)2(14%) 0(0%)0 
Resection  < 0.0001  n.s  n.s
GTR30(81%)3(21%) 5(83%)7(50%) 3(60%)2(29%) 
STR3(8%)3(21%) 1(17%)3(21%) 2(40%)4(57%) 
OB4(11%)8(57%) 0(0%)4(29%) 0(0%)1(14%) 
Radio  n.s  n.s  n.s
yes25(68%)9(64%) 4(67%)10(71%) 1(20%)4(57%) 
no8(22%)3(21%) 1(17%)3(21%) 3(60%)0(0%) 
unknown4(11%)2(14%) 1(17%)1(7%) 1(20%)3(43%) 
Chemo  n.s  n.s  n.s
yes6(16%)4(29%) 3(50%)7(50%) 1(20%)2(29%) 
no27(73%)8(57%) 2(33%)5(36%) 3(60%)2(29%) 
unknown4(11%)2(14%) 1(17%)2(14%) 1(20%)3(43%) 
IDH1  n.s  n.s  n.s
wildtype26(70%)11(79%) 4(67%)10(71%) 3(60%)4(57%) 
mutant0(0%)0(0%) 0(0%)0(0%) 0(0%)0(0%) 
unknown11(30%)3(21%) 2(33%)4(29%) 2(40%)3(43%) 
TERT promoter  n.s  n.s  n.s
wildtype17(46%)10(71%) 4(67%)8(57%) 3(60%)3(43%) 
mutant9(24%)1(7%) 0(0%)2(14%) 0(0%)1(14%) 
unknown11(30%)3(21%) 2(33%)4(29%) 2(40%)3(43%) 
BRAF V600E  n.s  0.0020  n.s
wildtype23(62%)10(71%) 1(17%)10(71%) 2(40%)4(57%) 
mutant3(8%)0(0%) 3(50%)0(0%) 1(20%)0(0%) 
unknown11(30%)4(29%) 2(33%)4(29%) 2(40%)3(43%) 
Ki-67  0.0108  n.s  n.s
< 10%28(76%)6(43%) 2(33%)1(7%) 0(0%)0(0%) 
≥10%7(19%)8(57%) 4(67%)13(93%) 5(100%)7(100%) 
unknown2(5%)0(0%) 0(0%)0(0%) 0(0%)0(0%) 
Median OS (months)Und24.23< 0.0001Und24.47n.s10.8312.10n.s
  1. C cervical vertebrae, C-T cervicothoracic vertebrae, T thoracic vertebrae, T-L thoracolumbar vertebrae, GTR gross total resection, STR subtotal resection, OB open biopsy, Radio Radiotherapy, Chemo Chemotherapy
  2. Significant P-values are indicated in bold text