Table 3 Comparison of the characteristics and prognoses of histological grade II–IV spinal cord glioma patients with or without the H3 K27M mutation
From: The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation
| Â | Histological Grade II | Histological Grade III | Histological Grade IV | ||||||
|---|---|---|---|---|---|---|---|---|---|
H3 wildtype | H3 K27M-mutant | P-value | H3 wildtype | H3 K27M-mutant | P-value | H3 wildtype | H3 K27M-mutant | P-value | |
Number | 37 | 14 | Â | 6 | 14 | Â | 5 | 7 | Â |
Age (year) | 29 | 36 | n.s | 30 | 35 | n.s | 51 | 20 | 0.0101 |
|  | (6–54) | (10–51) |  | (13–63) | (9–52) |  | (30–63) | (13–36) |  |
Gender | Â | Â | n.s | Â | Â | n.s | Â | Â | n.s |
male | 25(68%) | 7(50%) | Â | 4(67%) | 9(64%) | Â | 2(40%) | 2(29%) | Â |
female | 12(32%) | 7(50%) | Â | 2(33%) | 5(36%) | Â | 3(60%) | 5(71%) | Â |
Location | Â | Â | n.s | Â | Â | n.s | Â | Â | n.s |
C | 16(43%) | 5(36%) | Â | 1(17%) | 3(21%) | Â | 2(40%) | 2(29%) | Â |
C-T | 5(14%) | 1(7%) | Â | 0(0%) | 3(21%) | Â | 1(20%) | 3(43%) | Â |
T | 13(35%) | 7(50%) | Â | 4(67%) | 6(43%) | Â | 2(40%) | 2(29%) | Â |
T-L | 3(8%) | 1(7%) | Â | 1(17%) | 2(14%) | Â | 0(0%) | 0 | Â |
Resection |  |  | < 0.0001 |  |  | n.s |  |  | n.s |
GTR | 30(81%) | 3(21%) | Â | 5(83%) | 7(50%) | Â | 3(60%) | 2(29%) | Â |
STR | 3(8%) | 3(21%) | Â | 1(17%) | 3(21%) | Â | 2(40%) | 4(57%) | Â |
OB | 4(11%) | 8(57%) | Â | 0(0%) | 4(29%) | Â | 0(0%) | 1(14%) | Â |
Radio | Â | Â | n.s | Â | Â | n.s | Â | Â | n.s |
yes | 25(68%) | 9(64%) | Â | 4(67%) | 10(71%) | Â | 1(20%) | 4(57%) | Â |
no | 8(22%) | 3(21%) | Â | 1(17%) | 3(21%) | Â | 3(60%) | 0(0%) | Â |
unknown | 4(11%) | 2(14%) | Â | 1(17%) | 1(7%) | Â | 1(20%) | 3(43%) | Â |
Chemo | Â | Â | n.s | Â | Â | n.s | Â | Â | n.s |
yes | 6(16%) | 4(29%) | Â | 3(50%) | 7(50%) | Â | 1(20%) | 2(29%) | Â |
no | 27(73%) | 8(57%) | Â | 2(33%) | 5(36%) | Â | 3(60%) | 2(29%) | Â |
unknown | 4(11%) | 2(14%) | Â | 1(17%) | 2(14%) | Â | 1(20%) | 3(43%) | Â |
IDH1 | Â | Â | n.s | Â | Â | n.s | Â | Â | n.s |
wildtype | 26(70%) | 11(79%) | Â | 4(67%) | 10(71%) | Â | 3(60%) | 4(57%) | Â |
mutant | 0(0%) | 0(0%) | Â | 0(0%) | 0(0%) | Â | 0(0%) | 0(0%) | Â |
unknown | 11(30%) | 3(21%) | Â | 2(33%) | 4(29%) | Â | 2(40%) | 3(43%) | Â |
TERT promoter | Â | Â | n.s | Â | Â | n.s | Â | Â | n.s |
wildtype | 17(46%) | 10(71%) | Â | 4(67%) | 8(57%) | Â | 3(60%) | 3(43%) | Â |
mutant | 9(24%) | 1(7%) | Â | 0(0%) | 2(14%) | Â | 0(0%) | 1(14%) | Â |
unknown | 11(30%) | 3(21%) | Â | 2(33%) | 4(29%) | Â | 2(40%) | 3(43%) | Â |
BRAF V600E | Â | Â | n.s | Â | Â | 0.0020 | Â | Â | n.s |
wildtype | 23(62%) | 10(71%) | Â | 1(17%) | 10(71%) | Â | 2(40%) | 4(57%) | Â |
mutant | 3(8%) | 0(0%) | Â | 3(50%) | 0(0%) | Â | 1(20%) | 0(0%) | Â |
unknown | 11(30%) | 4(29%) | Â | 2(33%) | 4(29%) | Â | 2(40%) | 3(43%) | Â |
Ki-67 | Â | Â | 0.0108 | Â | Â | n.s | Â | Â | n.s |
< 10% | 28(76%) | 6(43%) |  | 2(33%) | 1(7%) |  | 0(0%) | 0(0%) |  |
≥10% | 7(19%) | 8(57%) |  | 4(67%) | 13(93%) |  | 5(100%) | 7(100%) |  |
unknown | 2(5%) | 0(0%) | Â | 0(0%) | 0(0%) | Â | 0(0%) | 0(0%) | Â |
Median OS (months) | Und | 24.23 | < 0.0001 | Und | 24.47 | n.s | 10.83 | 12.10 | n.s |