From: The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation
Histological Grade II | Histological Grade III | Histological Grade IV | |||||||
---|---|---|---|---|---|---|---|---|---|
H3 wildtype | H3 K27M-mutant | P-value | H3 wildtype | H3 K27M-mutant | P-value | H3 wildtype | H3 K27M-mutant | P-value | |
Number | 37 | 14 | 6 | 14 | 5 | 7 | |||
Age (year) | 29 | 36 | n.s | 30 | 35 | n.s | 51 | 20 | 0.0101 |
(6–54) | (10–51) | (13–63) | (9–52) | (30–63) | (13–36) | ||||
Gender | n.s | n.s | n.s | ||||||
male | 25(68%) | 7(50%) | 4(67%) | 9(64%) | 2(40%) | 2(29%) | |||
female | 12(32%) | 7(50%) | 2(33%) | 5(36%) | 3(60%) | 5(71%) | |||
Location | n.s | n.s | n.s | ||||||
C | 16(43%) | 5(36%) | 1(17%) | 3(21%) | 2(40%) | 2(29%) | |||
C-T | 5(14%) | 1(7%) | 0(0%) | 3(21%) | 1(20%) | 3(43%) | |||
T | 13(35%) | 7(50%) | 4(67%) | 6(43%) | 2(40%) | 2(29%) | |||
T-L | 3(8%) | 1(7%) | 1(17%) | 2(14%) | 0(0%) | 0 | |||
Resection | < 0.0001 | n.s | n.s | ||||||
GTR | 30(81%) | 3(21%) | 5(83%) | 7(50%) | 3(60%) | 2(29%) | |||
STR | 3(8%) | 3(21%) | 1(17%) | 3(21%) | 2(40%) | 4(57%) | |||
OB | 4(11%) | 8(57%) | 0(0%) | 4(29%) | 0(0%) | 1(14%) | |||
Radio | n.s | n.s | n.s | ||||||
yes | 25(68%) | 9(64%) | 4(67%) | 10(71%) | 1(20%) | 4(57%) | |||
no | 8(22%) | 3(21%) | 1(17%) | 3(21%) | 3(60%) | 0(0%) | |||
unknown | 4(11%) | 2(14%) | 1(17%) | 1(7%) | 1(20%) | 3(43%) | |||
Chemo | n.s | n.s | n.s | ||||||
yes | 6(16%) | 4(29%) | 3(50%) | 7(50%) | 1(20%) | 2(29%) | |||
no | 27(73%) | 8(57%) | 2(33%) | 5(36%) | 3(60%) | 2(29%) | |||
unknown | 4(11%) | 2(14%) | 1(17%) | 2(14%) | 1(20%) | 3(43%) | |||
IDH1 | n.s | n.s | n.s | ||||||
wildtype | 26(70%) | 11(79%) | 4(67%) | 10(71%) | 3(60%) | 4(57%) | |||
mutant | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | |||
unknown | 11(30%) | 3(21%) | 2(33%) | 4(29%) | 2(40%) | 3(43%) | |||
TERT promoter | n.s | n.s | n.s | ||||||
wildtype | 17(46%) | 10(71%) | 4(67%) | 8(57%) | 3(60%) | 3(43%) | |||
mutant | 9(24%) | 1(7%) | 0(0%) | 2(14%) | 0(0%) | 1(14%) | |||
unknown | 11(30%) | 3(21%) | 2(33%) | 4(29%) | 2(40%) | 3(43%) | |||
BRAF V600E | n.s | 0.0020 | n.s | ||||||
wildtype | 23(62%) | 10(71%) | 1(17%) | 10(71%) | 2(40%) | 4(57%) | |||
mutant | 3(8%) | 0(0%) | 3(50%) | 0(0%) | 1(20%) | 0(0%) | |||
unknown | 11(30%) | 4(29%) | 2(33%) | 4(29%) | 2(40%) | 3(43%) | |||
Ki-67 | 0.0108 | n.s | n.s | ||||||
< 10% | 28(76%) | 6(43%) | 2(33%) | 1(7%) | 0(0%) | 0(0%) | |||
≥10% | 7(19%) | 8(57%) | 4(67%) | 13(93%) | 5(100%) | 7(100%) | |||
unknown | 2(5%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | |||
Median OS (months) | Und | 24.23 | < 0.0001 | Und | 24.47 | n.s | 10.83 | 12.10 | n.s |