Fig. 4

Survival studies of orthotopic xenograft models in mice. a Kaplan-Meier-Survival curve after establishing tumors through intracranial injection of IOMM-KLF4^wt or -KLF4^K409Q cells in the convexity (IOMM-KLF4^wt vs IOMM-KLF4^K409Q) and exemplary MRI. No difference in OS was observed (p = .4305). b Exemplary MRI of KLF4^wt (I) and KLF4^K409Q (II) tumors and histological cross section of the KLF4^K409Q skull base tumor (III and IV). c Analysis of tumor size on MRI (n = 3). d Kaplan-Meier-Survival curve of mice bearing skull base tumors with and without treatement. e Combined Kaplan-Meier-Survival curve of both cell lines (KLF4^wt and KLF4^K409Q) with and without treatment