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Table 5 Summary of data for insoluble cytosolic proteins in 13 month old Tet.HuAβ treated with Dox

From: Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Genotypes Age assessed Total Aβ burden assessed by CS-silver stain # Animals # of cytosolic proteins identified as over-represented in SDS insoluble fractions
Pair-wise analysis
Combined with SAINT > 0.9
Tet.HuAβ 2.5 mo 3 0
13 mo +++ 4 80
13 mo + Dox 1wk +++ 3 52
13 mo + Dox 4 wk +++ 4 43
NTg 2.5 mo - 2 NA
13 mo - 2
13 mo + Dox 1wk - 2
13 mo + Dox 4 wk   2