Table 5 Summary of data for insoluble cytosolic proteins in 13 month old Tet.HuAβ treated with Dox
Genotypes | Age assessed | Total Aβ burden assessed by CS-silver stain | # Animals | # of cytosolic proteins identified as over-represented in SDS insoluble fractions |
|---|---|---|---|---|
Pair-wise analysis Combined with SAINT > 0.9 | ||||
Tet.HuAβ | 2.5 mo | – | 3 | 0 |
13 mo | +++ | 4 | 80 | |
13 mo + Dox 1wk | +++ | 3 | 52 | |
13 mo + Dox 4 wk | +++ | 4 | 43 | |
NTg | 2.5 mo | - | 2 | NA |
13 mo | - | 2 | ||
13 mo + Dox 1wk | - | 2 | ||
13 mo + Dox 4 wk | 2 |