Fig. 2

Analysis of changes in proteome solubility across the different models of amyloidosis. This graph plots the proteins identified by pair-wise comparison combined with SAINT analysis (≥ 0.9 probability and spectral count ≥5) for each protein identified in the SDS-insoluble fraction from each line of transgenic animals (raw data in Additional files 3 and 4, Tables S2 and S3). The X- axis was generated by the rank ordering of proteins that met criteria as over-represented in SDS-insoluble fractions from the highest to lowest spectral count numbers with the Y-axis plotting the average number of spectral counts (error bars indicate standard deviation). Note that the rank order of proteins identified differed between lines and therefore the data points between different lines of mice should not be viewed as aligning. Rather, the graphs provide an indication of relative number of spectra counts for proteins identified within each line