Fig. 1

The pathologic profile of the AD-amyloidosis models used in the study. All the images shown here are from mice that provided data for Table 2. The images shown are from tissues stained by the Campbell-Switzer silver (CS-Silver) method to detect all types of Aβ deposition, Thioflavin-S to detect cored deposits, anti-ubiquitin immunostaining to detect neuritic profiles, and anti-GFAP immunostaining to detect astrogliosis. Low power images of the entire hemibrain were captured by scanning microscopy with an Aperio system. At least 3 animals were used for the staining and a representative section from 2 or 3 sections per animal is shown. a Bri42Homo, b Tet.Bri42, c PrP.HuAβ/PS1, d PrP.MoAβ/PS1, e PrP.APPsi, f Tet.MoAβ, g Tet.HuAβ. Except for GFAP staining (amplification is 20x, scale bars 100 μm), all the other images were captured at 40x (scale bars 50 μm). See Additional file 1, Fig. S1 a-g for larger images and additional pathologic markers