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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Fig. 7

Model for the pathomechanisms involved in augmented depression-like behavior in HMBS-deficient mice. Aberrant mitochondrial activity is proposed as central pathological feature impacting on neurogenic and neuroplastic potential, as well as on myelination in the KI hippocampus, all of which may collectively contributed to enhanced depression-like behavior in HMBS-deficient mice

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