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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Fig. 6

Electrophysiological evaluation of hippocampal dentate gyrus synaptic plasticity in HMBS-deficient mice. a Schematic depiction of the placement of the electrodes for LTP recordings. b LTP of fEPSP after high frequency stimulation and c representative traces in HMBS-deficient (KI) and WT mice. d Input-output recordings and e paired-pulse inhibition of fEPSP to maximum fEPSP. All values are presented as mean ± SEM; n = 8–12 per genotype. Statistical significances displayed reflect results of repeated measure mixed model ANOVA. *p < 0.05; HMBS, hydroxymethylbilane synthase; LTP, long-term potentiation; fEPSP, field excitatory postsynaptic potential, MPP, medial perforant path; DG, dentate gyrus

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