Fig. 2

High-throughput RNA sequencing of hippocampal tissue of HMBS-deficient mice. a Results of enrichment analysis revealing a gene expression signature with relevance for myelination in KI mice. b Venn-diagram highlighting 3 genes found to be differentially expressed in KI as compared to WT mice which are also involved in depression and myelin deficits (n = 6 per genotype). AIP, acute intermittent porphyria; MOG, myelin oligodendrocyte glycoprotein; CNP, 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase; PLP1, myelin proteolipid protein 1 (CNS)