Table 3 Selected groups of significant GO terms overrepresented in genes correlated with age in female and male
Group | Term_female | P value_F | Term_male | P value_M |
|---|---|---|---|---|
Immunity | immune response | 2.16E-04 | negative regulation of immune system process | 1.25E-02 |
regulation of immune system process | 2.58E-04 | Â | Â | |
regulation of production of molecular mediator of immune response | 7.18E-03 | Â | Â | |
positive regulation of cytokine production involved in immune response | 1.67E-02 | Â | Â | |
leukocyte mediated immunity | 2.98E-02 | Â | Â | |
immune system process | 3.53E-02 | Â | Â | |
activation of immune response | 3.67E-02 | Â | Â | |
regulation of innate immune response | 4.00E-02 | Â | Â | |
immunoglobulin secretion | 4.47E-02 | Â | Â | |
negative regulation of immune response | 4.80E-02 | Â | Â | |
Inflammation | positive regulation of inflammatory response | 6.21E-03 | acute inflammatory response | 1.69E-02 |
regulation of inflammatory response | 6.90E-03 | Â | Â | |
acute inflammatory response | 1.12E-02 | Â | Â | |
ROS | regulation of reactive oxygen species biosynthetic process | 5.79E-04 | positive regulation of reactive oxygen species metabolic process | 2.63E-03 |
positive regulation of reactive oxygen species metabolic process | 2.72E-03 | regulation of reactive oxygen species biosynthetic process | 6.00E-03 | |
response to oxidative stress | 2.22E-02 | response to oxidative stress | 3.94E-02 | |
intrinsic apoptotic signaling pathway in response to oxidative stress | 3.64E-02 | Â | Â | |
Integrin-associated terms | integrin-mediated signaling pathway | 1.67E-05 | integrin-mediated signaling pathway | 2.72E-04 |
integrin binding | 7.38E-03 | cell adhesion mediated by integrin | 3.53E-02 | |
| Â | Â | integrin binding | 2.83E-04 |