Fig. 3

CA1 Tg mice undergo mitochondrial stress. a WB analysis of extracts from 6-mo Wt and Tg mice CA1 (Wt, n = 6; Tg, n = 7), using antibodies against SIRT3, SOD2 and acetylated SOD2. b WB analysis of extracts from 12-mo Wt and Tg mice hippocampi (Wt, n = 5; Tg, n = 5). Data are presented as mean ± SEM (**P < 0.01; ***P < 0.001). WB analysis of extracts from 6-mo Wt and Tg mice CA1 (Wt, n = 6; Tg, n = 5) (c), and from 12-mo Wt and Tg mice hippocampi (Wt, n = 5; Tg, n = 5) (d) for PINK1 and LC-3. Data are presented as mean ± SEM, *P < 0.05. WB analysis of extracts from 6-mo WT and Tg mice CA1 (WT, n = 5; Tg, n = 6) (e), and from 12-mo WT and Tg mice hippocampi (WT, n = 5; Tg, n = 5) (f) for TFAM. Data are presented as mean ± SEM (*P < 0.05), **P < 0.01). Actin was used as loading control