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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Fig. 7

Molecular signature of NAWM and CD26/DPP4 expression. a. The top ten up- and downregulated DEGs in NAWM compared to control WM. b. The 16 uniquely expressed DEGs in NAWM. c. The RNA expression level of CD26/DPP4 in the NAWM, chronic active remyelinating, active and inactive lesions. d. The protein expression of CD26/DPP4 in the NAWM and absence in control WM. e. The co-localization of CD26/DPP4 with IBA1 in the NAWM. f. Expression of CD26/DPP4 at a vessel in an active lesion. FDR: false discovery rate; DEGs: differentially expressed genes (FDR < 0.05); WM: white matter; NAWM: normal appearing WM

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