Fig. 5

Lesion/specific biological processes and cellular locations. a. The bar chart shows the number of biological processes in the different lesion types (active, inactive, chronic active, remyelinating) based on the lesion-specific DEGs. We have classified them in six groups: “immune-related”, “cell activation and extracellular transduction”, “protein modifications”, “metabolic processes”, “extracellular secretion and exocytosis”, and “brain (neuron) specific”. b. The circle diagram for each lesion type (active, inactive, chronic active) represents the percentage of cellular components identified from the lesion-specific DEGs and grouped in “granules”, “vesicles”, “extracellular space”, “cytoplasm”, “mitochondria” and “brain (neuron) specific”. No predefined cellular component was predicted for remyelination. FDR: false discovery rate; DEGs: differentially expressed genes (FDR < 0.05)