Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Table 4 Distribution of CD3 (+), CD20 (+), IL-4 (+) and IFNγ (+) cells/mm² in MS brain tissue

	NAWM	Active WML	Chronic-active WML	NAGM	Subpial GML
CD3	2.0 ± 1.0	45.6 ± 14.5**	19.4 ± 4.2**	0.2 ± 0.1	0.7 ± 0.4
CD20	1.1 ± 0.4	4.3 ± 2.5	2.1 ± 0.6	0.4 ± 0.2	0.5 ± 0.3
IL-4	0.5 ± 0.4	1.1 ± 1.1	2.3 ± 0.6*	0.0 ± 0.0	0.0 ± 0.0
IFN-γ	0.2 ± 0.1	5.7 ± 2.8*	1.1 ± 0.5	0.0 ± 0.0	0.0 ± 0.0

Counts of CD3, CD20 and IL-4 (+) and IFNγ (+) cells in the NAWM (N = 18), active WMLs (N = 10), chronic-active WMLs (N = 7), NAGM (N = 15), subpial GMLs (N = 9). Data is presented as mean +/− SEM
* = p < 0.05, ** < p < 0.01

ISSN: 2051-5960