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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Fig. 1

Increased pathology in temporal compared to occipital cortex and in APOE4 compared to APOE3 carriers. Representative images of immunohistochemistry for amyloid beta (a) tau (b) (brown) and Hematoxylin and Eosin counterstain for cells (blue) highlight the higher pathological load in APOE4 carriers than APOE3 carriers and more pathology in superior temporal gyrus (BA41/42) compared to primary visual cortex (BA17). For analysis, we examined ratios of AD vs control samples in the 2 brain regions and with APOE3/3 or APOE3/4 genotype to examine how the synaptic proteome changes with differential pathology (c). Scale bars represent 200 μm (a) 50 μm (b)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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