Fig. 4
From: Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL
No blood brain barrier (BBB) leakage in the white matter of CADASIL mice. a-c Immunofluorescent images showing fibrinogen (green) and capillaries (glut-1; white) in the anterior corpus callosum (CC) of Col4a1+/G498V (a), TgNotch3WT (b), and TgNotch3R169C (c) mice. Fibrinogen staining is quantified in both the anterior and posterior CC (d). e-g Fluorescent images showing injected cadaverine (red) and capillaries (glut-1; white) in the anterior CC of Col4a1+/G498V (e), TgNotch3WT (f), and TgNotch3R169C (g) mice. Cadaverine leakage is quantified in both the anterior and posterior CC (h). Mean ± SEM; ****: p < 0.0001; two-way ANOVA with Tukey’s post-hoc tests; n for each group shown on graphs. Scale bar: 25 μm