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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Fig. 5

Altered expression of DNA repair genes in mTBI brains compared to controls, expressed as log2 RNA count number. In a, significantly down-regulated DNA repair genes (n = 37) are: MSH4 (p = 0.0001), FANCA (p = 0.0001), POLD1 (p = 0.0002), NBN (p = 0.001), RAD23B (p = 0.0001), APEX1 (p = 0.004), POLB (p = 0.003), MBD4 (p = 0.007), RAD9A (p = 0.005), ERCC2 (p = 0.01), XPA (p = 0.02), ERCC8 (p = 0.02), XAB2 (p = 0.02), CETN2 (p = 0.02), DMC1 (p = 0.004), XRCC6 (p = 0.002), PMS1 (p = 0.03), XRCC3 (p = 0.03), H2AFX (p = 0.004), BMI1 (p = 0.04) PMS2 (p = 0.003), RAD21 (p = 0.02), MSH3 (p = 0.02), MLH3 (p = 0.04), ERCC3 (p = 0.01), RAD23A (p = 0.01), RAD51C (p = 0.0001), NEIL2 (p = 0.02), MDC1 (p = 0.007), RNF168 (p = 0.02), MSH2 (p = 0.0001), XRCC5 (p = 0.003), NTHL1 (p = 0.02), RPA2 (p = 0.002), NEIL1 (p = 0.006), RAD50 (p = 0.04). In b, significantly up-regulated DNA repair genes (n = 9) are: RAD51B (p = 0.03), RAD52 (p = 0.05), RAD18 (p = 0.05), RAD54L (p = 0.05), MSH5 (p = 0.03), BRCA2 (p = 0.01), MAG1 (p = 0.05), TDG (p = 0.04), NEIL3 (p = 0.03)

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