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Table 2 Multivariate Cox-regression analysis. Mitotic activity was analyzed as continuous parameter

From: Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort

Event-free Survival

Covariate

Coefficient

StdErr

Wald Chi-Square

P Value

1q Gain

0.684

0.272

6,295

0.012

Resection

1.053

0.255

17,072

<0.001

Mitotic activity (cont.)

0.008

0.003

5.826

0.016

Covariate

Hazard Ratio

95%Conf-L

95%Conf-U

 

1q Gain

1.964

1.161

3.389

 

Resection

2.866

1.739

4.723

 

Mitotic activity (cont.)

1.008

1.002

1.015

 

Overall Survival

Covariate

Coefficient

StdErr

Wald Chi-Square

P Value

1q Gain

0.897

0.374

5.754

0.016

Resection

1.124

0.381

8.703

0.003

Mitotic activity (cont.)

0.015

0.005

10.574

0.001

Necrosis

0.739

0.763

0.937

0.333

Vascular proliferation

1.431

0.752

3.619

0.057

Covariate

Hazard Ratio

95%Conf-L

95%Conf-U

 

1q Gain

2.453

1.178

5.107

 

Resection

3.078

1.458

6.496

 

Mitotic activity (cont.)

1.015

1.006

1.024

 

Necrosis

2.094

0.469

9.351

 

Vascular proliferation

4.181

0.958

18.253