Table 3 Morphologic data
Patient | Sex | Age at biopsy (years) | Biopsied muscle | Light microscopy | Electron microscopy (EM) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HE | PAS | Immunohisto-chemistry (IHC) | |||||||||||||
Internalized nuclei | Fibrotic areas | Vacuoles | Ring fibers | Necrosis | Regeneration | Intensity | Positive vacuoles | SQSTM1/p62 | Inter-myofibrillar glycogen accumulation | Autophago-somes | Autophagic structures | ||||
P1 | M | 55 | L. Deltoid | ++ | ++ | +++ | + | – | – | ++ | +++ | NP | + | + | – |
P2 | F | 35 | L. Deltoid | + | + | +++ | ++ | – | + | + | +++ | NP | ++ | ++ | – |
P3 | M | 28 | L. Deltoid | ++ | + | + | ++ | – | – | ++ | ++ | NP | + | ++ | ++ |
P4 | F | 59 | L. Palmaris | ++ | ++ | +++ | ++ | – | ++ | ++ | +++ | NP | + | ++ | + |
P5 | F | ND | ND | ++ | +++ | ++ | ++ | – | + | ++ | ++ | NP | +++ | ++ | + |
P6 | F | ND | ND | ++ | ++ | ++ | + | – | – | + | ++ | NP | ++ | + | ++ |
P7 | M | 40 | L. Deltoid | ++ | +++ | +++ | + | – | – | +++ | +++ | NP | + | + | – |
P8 | M | 33 | ND | +++ | + | ++ | ++ | – | + | ++ | ++ | NP | ++ | ++ | – |
P9 | F | 53 | L. Vastus lateralis | + | ++ | + | ++ | – | – | +++ | + | NP | + | ++ | – |
P10 | M | 6 | ND | +++ | ++ | ++ | + | – | – | + | ++ | NP | ++ | + | + |
P11 | M | 22 | ND | + | +++ | ++ | – | – | – | ++ | ++ | + | + | + | + |
P12 | F | 16 | L. Biceps brachii | + | ++ | ++ | – | – | – | +++ | + | + | NP | NP | NP |
P13 | M | ND | L. Biceps brachii | ++ | ++ | ++ | – | – | – | + | – | + | NP | NP | NP |
P14 | M | 7 | L. Biceps brachii | + | + | + | – | – | – | + | – | + | NP | NP | NP |
P15 | M | 15 | L. Deltoid | + | + | + | – | – | – | +++ | + | + | NP | NP | NP |
P16 | F | 3 | L. Biceps brachii | + | ++ | +++ | – | – | – | +++ | ++ | + | NP | NP | NP |
P17 | M | 24 | L. Biceps brachii | ++ | + | +++ | – | – | – | + | + | – | NP | NP | NP |
P18 | F | 38 | R. Rectus femoris | +++ | +++ | +++ | – | – | – | + | + | + | NP | NP | NP |
P19 | M | 23 | L. Biceps brachii | + | + | ++ | – | – | – | +++ | +++ | + | NP | NP | NP |
P20 | M | 53 | L. Biceps brachii | ++ | + | +++ | – | + | ++ | + | + | + | NP | NP | NP |
P21 | M | 56 | L. Biceps brachii | ++ | – | ++ | – | + | + | ++ | + | + | NP | NP | NP |
P22 | M | 58 | L. Biceps brachii | +++ | + | + | ++ | – | – | +++ | ++ | – | NP | NP | NP |
P23 | M | 48 | L. Biceps brachii | +++ | + | +++ | – | – | + | +++ | ++ | – | NP | NP | NP |
P24 | F | 46 | L. Vastus medialis | +++ | +++ | +++ | – | – | – | +++ | ++ | NP | NP | NP | NP |
P25 | F | 46 | L. Vastus lateralis | + | +++ | +++ | – | – | + | +++ | +++ | NP | + | +++ | – |
P26 | M | 24 | L. Vastus lateralis | +++ | ++ | +++ | – | – | +++ | +++ | +++ | NP | + | ++ | – |
P27 | M | 30 | L. Vastus lateralis | +++ | +++ | +++ | – | – | +++ | +++ | ++ | NP | +++ | + | – |
P28 | F | 49 | Tibial anterior | + | +++ | +++ | – | – | ++ | + | +++ | NP | + | ++ | – |
P29 | M | 50 | L. Vastus lateralis | ++ | ++ | ++ | – | – | +++ | +++ | ++ | NP | ++ | ++ | – |
P30 | M | 49 | L. Vastus lateralis | ++ | ++ | +++ | +++ | – | + | ++ | +++ | NP | NP | NP | NP |