Fig. 4

Representative confocal microscopy images showing tau aggregates in cells exposed to AD and CTE temporal cortex brain lysates (white arrow heads). No aggregates where detected in cells exposed to temporal cortex brain lysates from controls free of tau pathology (a). Quantification of IFD in ROIs from controls (n = 6), CTE (n = 5) and AD (n = 9) brain samples. IFD was significantly higher in AD than in CTE and control samples (p = 0.0009) (b). IFD values showed a significant correlation with total tau burden quantified by IHC (c) and with total levels tau oligomers (e), p-tau monomers (f) and p-tau monomers (g) but not with total tau monomers (d). Spearman r and p values are displayed on the graphs. Abbreviations: HPC: hipoccampus; FC: frontal cortex; TC: temporal cortex; PC: parietal cortex; OC: occipital cortex; IFD: integrated FRET density; IHC: immunohistochemistry. Scale bar = 100 μm