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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments

Fig. 3

PAI-1 deficiency is associated with reduced levels of serotonin and dopamine. Concentrations of serotonin (5-HT), noradrenalin (NA) and dopamine (DA) in PAI-1 knockout mice (PAI-1−/−) and their wild-type littermates (PAI-1+/+). Ultra-high-pressure liquid chromatography coupled with tandem-mass spectrometry was performed in the prefrontal cortex (a), hippocampus (b), hypothalamus (c) and dorsal raphe (d). n = 5 for each structure / genotype. Mann-Whitney U-tests: **P < 0.01. Boxplots show distributions with black horizontal lines indicating the median, box margins denoting the lower and upper quartiles. Whiskers show the minimum and maximum values

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Acta Neuropathologica Communications

ISSN: 2051-5960

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