Fig. 1
PAI-1 deficiency induces a depressive-like phenotype. Evaluation of the behavioral phenotype of PAI-1 knockout mice (PAI-1−/−) and of their wild-type littermates (PAI-1+/+). a Splash test: nPAI-1+/+ = 34; nPAI-1 −/− = 41. b Coat state: nPAI-1+/+ = 35; nPAI-1−/− = 42. c Sucrose preference test: nPAI-1+/+ = 35; nPAI-1−/− = 39. d Body weight: nPAI-1+/+ = 15; nPAI-1−/− = 15. e Actimetry: nPAI-1+/+ = 35; nPAI-1−/− = 42. f Rotarod: nPAI-1+/+ = 33; nPAI-1−/− = 40. g, h T-maze: nPAI-1+/+ = 12; nPAI-1−/− = 9. Mann-Whitney U-tests (a, b), Student t tests (c-f), Wilcoxon signed-rank tests (g, h): *P < 0.05, **P < 0.01, ***P < 0.001. Boxplots show distributions with black horizontal lines indicating the median, box margins denoting the lower and upper quartiles. Whiskers show the minimum and maximum values