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Table 1 Differentially secreted proteins from control and Smn KD H-2Kb-BL6 muscle cells (p < 0.05)

From: Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy

Gene name

Protein name

# of unique peptides

P value

Fold change

SmnKD/Cont

GO/KEGG

Vapa

Vesicle-associated membrane protein-associated protein A

2

0.0028

4.903

Tight junction

Cxcl1

Fractalkine

3

0.0220

1.365

Chemokine signaling

exosome

Dpp2

Dipeptidyl peptidase 2

5

0.0063

1.286

exosome

Serpinh1

Serpin H1

15

0.0331

1.182

 

Timp1

Metalloproteinase inhibitor 1

6

0.0293

1.167

Exosome

Alad

Delta-aminolevulinic acid dehydratase

7

0.0132

1.165

 

Col4a1

Arresten;Collagen alpha-1(IV) chain

33

0.0209

1.140

Extracellular matrix, exosome

Lgals1

Galectin-1

8

0.0142

1.139

exosome

Serpine2

Glia-derived nexin

9

0.0386

1.109

exosome

Rcn1

Reticulocalbin-1

6

0.0138

1.101

Ca2+ binding

Msn

Moesin

23

0.0140

1.071

Actin cytoskeleton, cell junction, exosome

Lgal3bp

Galectin-3-binding protein

5

0.0353

1.070

exosome

Lsyna1

Inositol-3-phosphate synthase 1

7

0.0411

0.920

 

Atp5j2

ATP synthase subunit f, mitochondrial

1

0.0414

0.914

ATP synthesis, oxidative `phosphorylation

Tbl1xr1

F-box-like/WD repeat-containing protein TBL1XR1

2

0.0346

0.907

Wnt pathway,

Actn2

Alpha-actinin-2

22

0.0364

0.885

Cell junction, actin cytoskeleton

Xirp1

Xin actin-binding repeat-containing protein 1

4

0.0295

0.871

Cell junction, actin cytoskeleton

Uqcrc1

Cytochrome b-c1 complex subunit 1, mitochondrial

7

0.0206

0.852

Oxidative phosphorylation, Alzheimer’s, Parkinson’s, Huntington diseases

Phb2

Prohibitin-2

7

0.0082

0.845

 

Ermp1

Endoplasmic reticulum metallopeptidase 1

2

0.0099

0.841

 

Col4a2

Canstatin; Collagen alpha-2(IV) chain

36

0.0454

0.655

Focal adhesion, exosome

Col5a2

Collagen alpha-2(V) chain

37

0.0008

0.592

Focal adhesion, exosome

C1qtnf3

Complement C1q tumor necrosis factor-related protein 3

3

7.77E-0.5

0.455

Glucose homeostasis, exosome

Cp

Ceruloplasmin

2

0.0313

0.402

Cu-oxidase, exosome

Serpinc1

Antithrombin-III

5

0.0049

0.391

Complement and coagulation cascades, endopeptidase inhibitor, exosome

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Acta Neuropathologica Communications

ISSN: 2051-5960

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