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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Fig. 4

TDP-43Q331K-mediated dendritic spine defects in the motor cortex are partially suppressed by Sarm1 deletion. a. Representative images of the Thy1-YFP motor cortex apical dendrites from Layer V cortical neurons (upper), and the corresponding Neurolucida tracing (middle; Red = thin spine, Pink = stubby spine, Blue = mushroom spine) from mice of each genotype at 10 months of age. Scale bar, 5 μm. Examples of different spine morphologies (lower) [28]. b. Density of apical dendritic spines per micrometre in motor cortex. ANOVA P = 0.0016. Pairwise comparisons: NTG vs. Q331K-Sarm1+/−: ** P = 0.0014; Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: * P = 0.0268. (c-e) Spines were classified either as mushroom, stubby or thin type according their morphologic features. Density of each type of apical dendritic spines per millimetre in motor cortex. c. Thin spine density: ANOVA P = 0.0034. Pairwise comparisons: NTG vs. Q331K-Sarm1+/−: ** P = 0.0034; Q331K-Sarm1+/− vs. Q331K-Sarm1−/−: * P = 0.0227. d. Stubby spine density E. Mushroom spine density. For (b-e) (n = 5 mice per genotype); one-way ANOVA followed by Holm-Sidak post-hoc test for pairwise comparisons; error bars represent mean ± s.e.m

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