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Table 3 Differential Expression (Specific Comparisons)

From: Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Order

C9Plus vs. C9Minus

C9Plus vs. Control

Gene

Chr

P-value

FDR

FC

Gene

Chr

P-value

FDR

FC

1

C9orf72

chr9

4.35E-10

6.04E-06

-1.75

C9orf72

chr9

4.48E-10

1.08E-05

-1.69

2

FBLL1

chr5

5.01E-10

6.04E-06

1.88

SMIM14

chr4

3.16E-09

3.80E-05

-1.34

3

VSTM2A-OT1

chr7

1.51E-09

9.64E-06

1.96

PYCR2

chr1

5.96E-09

3.99E-05

-1.73

4

KCNJ6

chr21

1.88E-09

9.64E-06

1.92

NT5DC1

chr6

9.62E-09

3.99E-05

-1.57

5

ABCE1

chr4

2.06E-09

9.64E-06

-1.35

GID4

chr17

1.08E-08

3.99E-05

1.33

6

SMIM14

chr4

2.40E-09

9.64E-06

-1.25

GIT1

chr17

1.10E-08

3.99E-05

1.63

7

HRH3

chr20

4.12E-09

1.40E-05

1.99

SCN3A

chr2

1.16E-08

3.99E-05

1.94

8

SH3GL1P3

chr17

4.65E-09

1.40E-05

1.80

S100B

chr21

1.38E-08

4.17E-05

-1.94

9

CTD-2126E3.4

chr19

5.61E-09

1.50E-05

2.11

CMTM5

chr14

1.71E-08

4.57E-05

-2.49

10

LRFN4

chr11

7.15E-09

1.72E-05

1.69

RP11-196E1.3

chr11

1.96E-08

4.72E-05

-2.90

11

RP11-147 L13.13

chr17

1.02E-08

2.24E-05

1.80

DCTN6

chr8

3.88E-08

6.82E-05

-1.33

12

CA7

chr16

1.14E-08

2.28E-05

1.69

SUCLG2

chr3

4.11E-08

6.82E-05

-1.72

13

MXD4

chr4

1.36E-08

2.47E-05

1.35

MARCKSL1

chr1

4.16E-08

6.82E-05

-1.57

14

STX12

chr1

1.43E-08

2.47E-05

-1.23

KCNG1

chr20

4.17E-08

6.82E-05

2.88

15

ATG4D

chr19

1.73E-08

2.78E-05

1.30

BAG2

chr6

4.25E-08

6.82E-05

1.47

16

DUSP14

chr17

1.84E-08

2.78E-05

1.34

RAF1

chr3

5.09E-08

7.67E-05

1.23

17

CHMP2B

chr3

1.97E-08

2.78E-05

-1.32

TESK1

chr9

5.57E-08

7.81E-05

1.33

18

LPHN1

chr19

2.08E-08

2.78E-05

1.43

BDNF-AS

chr11

6.20E-08

7.81E-05

-1.82

19

ST8SIA5

chr18

2.31E-08

2.93E-05

1.52

CTC-273B12.10

chr19

6.57E-08

7.81E-05

2.69

20

NFATC2IP

chr16

2.55E-08

3.07E-05

-1.29

CYP4F11

chr19

6.61E-08

7.81E-05

-3.25

  1. Differentially expressed genes are shown when comparing patients with an expanded C9orf72 repeat to those without this repeat (C9Plus vs. C9Minus) or to control subjects (C9Plus vs. Control). For each gene, the chromosome (Chr), p-value, false discovery rate (FDR), and fold-change (FC) are displayed. Of note, this table has been generated after adjustment for cell-type-specific markers
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Acta Neuropathologica Communications

ISSN: 2051-5960

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