Fig. 5

a For patients harboring a C9orf72 repeat expansion and those without this expansion (C9Plus vs. C9Minus; module membership > 0.6 and significance < 1.0E-06), a gene network is displayed. b A gene network is visualized when examining expansion carriers and controls (C9Plus vs. Control; module membership > 0.6 and significance < 2.5E-05). In these network plots, the connectivity of each gene is represented by the size of its node, the module to which it has been assigned by its color, and the strength of the correlation by the thickness of its edges; the C9orf72 gene is denoted by an arrow. Of note, the plots in this figure have been generated after adjustment for cell-type-specific markers