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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Fig. 4

Ultrastructural examples of autolysis of human brain samples with long PMI prepared with standard embedding and hybrid freezing. Tissue sample from case 4, where the chromatin within the nuclei turns coarse (visible in a and c, arrows), and the mitochondria swell (visible in c and d, arrow heads). Both phenomena were visible either with standard embedding (a, b), or with hybrid freezing and cryo-substitution cocktail I (c, d). Scale bars = 0.5 μm

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