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Table 3 Semi-quantitative grading of astrocytic αsyn pathology

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Astrocyte pathology
  SNpc Amyg. Cing.
LBD
 Case 1 +++
 Case 2 +++
 Case 3 ++
 Case 4 ++
 Case 5 ++
 Case 6 +
 Case 7 +++
 Case 8 ++
 Case 9 ++
AD/ALB
 Case 15
 Case 16
 Case 17 +
 Case 18 +
 Case 19
 Case 20
 Case 21
 Case 22
 Case 23 +
  1. Following immunohistochemical staining with central αsyn antibody 3H11 and formic acid retrieval, semi-quantitative grading was assigned to each LBD and AD/ALB case for 3 separate regions (SNpc substantia nigra pars compacta, cing. cingulate cortex, amyg. amygdala). The presence of astrocytic inclusions based on morphology was semi-quantitatively graded at 10x magnification on a multi-tiered scale, with “-” representing non-reactivity, “+” mild, “++” moderate, and “+++” representing the strongest level of reactivity