Astrocyte pathology |
|---|
| | SNpc | Amyg. | Cing. |
|---|
LBD |
Case 1 | – | +++ | – |
Case 2 | – | +++ | – |
Case 3 | – | ++ | – |
Case 4 | – | ++ | – |
Case 5 | – | ++ | – |
Case 6 | – | + | – |
Case 7 | – | +++ | – |
Case 8 | – | ++ | – |
Case 9 | – | ++ | – |
AD/ALB |
Case 15 | – | – | – |
Case 16 | – | – | – |
Case 17 | – | + | – |
Case 18 | – | + | – |
Case 19 | – | – | – |
Case 20 | – | – | – |
Case 21 | – | – | – |
Case 22 | – | – | – |
Case 23 | – | + | – |
- Following immunohistochemical staining with central αsyn antibody 3H11 and formic acid retrieval, semi-quantitative grading was assigned to each LBD and AD/ALB case for 3 separate regions (SNpc substantia nigra pars compacta, cing. cingulate cortex, amyg. amygdala). The presence of astrocytic inclusions based on morphology was semi-quantitatively graded at 10x magnification on a multi-tiered scale, with “-” representing non-reactivity, “+” mild, “++” moderate, and “+++” representing the strongest level of reactivity
