Fig. 6

Comparison of LRP in the amygdala of LBD versus AD/ALB across a panel of αsyn antibodies. a Representative sections of dense amygdala pathology from a LBD case labeled with 5 different αsyn antibodies without or with FA retrieval, as indicated. Insets display cortical LBs and αsyn-positive neurites. In the LBD amygdala, extensive neuritic pathology is detected for multiple antibodies when FA retrieval was used. The robust increase in apparent Lewy pathology with FA treatment is mainly seen in neuritic and possible glial processes; the amount of cortical LBs per visual field remain the same regardless of antibody or FA treatment. This immunohistochemical staining profile contrasts with the only modest increase in detected pathology seen in the LBD SNpc and cingulate cortex. Scale bar 50 μm. b Stained sections of amygdala pathology from an AD/ALB case labeled with 5 different αsyn antibodies without or with FA retrieval, as indicated. Insets display cortical LBs and αsyn-positive neurites. In the AD/ALB amygdala, neuritic pathology is modestly enhanced for multiple antibodies when FA retrieval is used; however, the density of neuropil αsyn staining pathology in LBD is not apparent in AD/ALB. Scale bar 50 μm