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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Fig. 2

Comparison of LRP between LBD and AD/ALB. a Representative sections of the SNpc from 4 AD/ALB and 4 LBD cases stained with pSer129 αsyn antibody EP1536Y. Abundant LNs and LBs (red arrows) are seen within pigmented neurons in all LBD cases, however AD/ALB cases display only rare examples of thread like neurites. Insets display LBs in pigmented neurons. b Representative sections of the amygdala from AD/ALB versus LBD cases labeled with antibody EP1536Y. Cortical-type LBs are apparent in dense patches within amygdalas of either disease type, however abundant thread-like neurites are more apparent in LBD cases compared with AD/ALB. Insets highlight cortical LBs or neurites. c Representative sections of the cingulate cortex from AD/ALB compared with LBD using antibody EP1536Y. LRP is entirely absent in all examined AD/ALB cases, whereas LBD cases display extensive LBs in deeper cortical layers and dot like inclusions in more superficial layers. Case numbers are indicated in lower right corner. Scale bar 100 μm

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