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Table 1 Summary of antibody staining in control and FXTAS patient tissue

From: Neuropathology of RAN translation proteins in fragile X-associated tremor/ataxia syndrome

Brain Region Case Age Sex UB p62 UBQLN2 Nterminal FMRpolyG Cterminal FMRpolyG
Hippocampus Control 1 59 N/A ++ + ++ + +
2 71 M + +
3 39 M +
4 47 M + +
FXTAS 1 74 M ++++ ++++ +++ ++++ +
2 78 M +++ ++ ++++ ++++ +
3 80 M ++++ ++ + ++ ++
4 69 M ++++ +++ ++ ++ ++
Cortex Control 2 71 M +
4 47 M + + + +
5 84 M ++++ +++
6 78 M ++++ ++++
FXTAS 1 74 M ++++ ++ + ++++ +
2 78 M ++ ++ ++++ +
3 80 M ++++ + + +
  1. -, negative; +, low-intensity staining; ++, moderate-intensity staining; +++, high-intensity staining; ++++, high-intensity and frequent staining. UBQLN2 ubiquilin 2, N/A not available; M, male