Fig. 8
From: Total copy number variation as a prognostic factor in adult astrocytoma subtypes
Pie charts illustrating (a) the relative frequency of cases with chromothripsis in all 5 astrocytoma subgroups, showing a statistically significant difference between IDH-mut LGGs without CDK4 amplification or CDKN2A/B deletion and IDH-mut GBMs (p = 0.0132) and between IDH-mut LGGs without CDK4 amplification or CDKN2A/B deletion and all IDH-mut tumors with poor clinical outcome (groups 2 + 3; p = 0.0211). Pie charts illustrating (b) the relative frequency of cases with mutations involving genes related to preservation of overall chromosomal stability in all 5 astrocytoma subgroups, showing a statistically significant difference between IDH-mut LGGs without CDK4 amplification or CDKN2A/B deletion and LGGs with those molecular alterations (p = 0.0197) and between IDH-mut LGG without CDK4 amplification or CDKN2A/B deletion and IDH-mut GBMs (p = 0.0086)