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Table 1 Patients’ characteristics of our study cohort

From: Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients

Study cohort n=111

 

n

%

Gender

Female

48

43

Male

63

57

Age in years

Mean

58.9

-

Median

61.2

-

Range

18-85.4

-

MGMT

Meth. (mean ≥10%)

56

51

Unmeth. (mean < 10%)

55

49

Toxicity during 1st line therapy

CTG °III-IV

4

4

2nd line therapy

mTMZ

38

34

TMZ rechallenge

7

6

CCNU+Procarbazine

4

4

BEV

3

3

Re-irradiation

4

4

TTFields

5

5

Re-resection

33

30

Follow up in months

Mean

19.4

-

Median

15.4

-

Range

0.3-90

-

Lost to follow up

2

2

PFS in months

Mean

12

-

Median

7.8

-

Range

0.3-56

-

OS in months

Mean

19.8

-

Median

15.5

-

Range

0.5-90

-

  1. BEV bevacizumab, CCNU lomustin, CTG common toxicity criteria, GTR gross total resection, MGMT O6-methylguanine-DNA-methyltransferase, meth methylated, mTMZ metronomic temozolomide, OS overall survival, PR partial resection, TMZ temozolomide, TTFields tumor treating fields, unmeth  unmethylated