Fig. 3
IT delivery of rAAV1-HGF ameliorated disease progression and prolonged the survival rate of SOD1-G93A TG mice. a-f SOD1-G93A TG mice at P60 were intrathecally injected with 5 × 1011 GC of rAAV1-C or rAAV1-HGF. Behavioral tests including those for forelimb strength (a), hindlimb strength (b), rotarod (c), and hanging wire (d) were performed, and body weight (e) was measured once a week until P158. In Fig. 3a-e, one-way ANOVA was performed followed by Tukey’s post-hoc test at each time point. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. f Survival curve was drawn based on Mantel-Cox and Gehan-Breslow-Wilcoxon tests for comparing two groups. In the Gehan-Breslow-Wilcoxon test, p value was 0.0115. Median survival days were 145.5 for the rAAV1-C-treated group, and 155 for the rAAV1-HGF-treated group. For graphs, values are represented as mean ± SEM